Osteoporosis – A Compound in Cannabis Hardens Bones

Another study has recently been published that demonstrates how plant-based compounds can aid in the prevention of osteoporosis, a brittle bone disease. Cannabidiol, a non-psychoactive compound found in cannabis, has been discovered to help preserve bone strength by scientists at the University of Aberdeen’s Institute of Medical Sciences.
The endocannabinoid system is a collection of cell receptors that are regulated by a combination of endogenous lipids and cannabis-derived compounds. Cannabinoid receptors play a role in a number of physiological processes, including appetite regulation, pain, memory, and mood. Since the receptors are well expressed on osteoclasts, cells whose primary role is to resorb (thin out) bone, recent research has shown that the endocannabinoid system has a significant effect on bone metabolism.Do you want to learn more? Visit Top Shelf Wellness Center Recreational Marijuana Dispensary – cannabis

Bone is a living, active tissue that is constantly being created, remodelled, and transformed in response to the body’s physical and physiological needs. The substance that makes up both the thick sections of the bone and the bone marrow layer is bone matrix, which is mainly composed of the macronutrients calcium, magnesium, and phosphate. Many people already believe that eating foods high in these minerals would protect them from osteoporosis. This is not always the case, according to epidemiological and other facts.
The integrated mechanisms that regulate the formation and resorption of bone are just as important as the availability of calcium, magnesium, and phosphate when it comes to bone health and disease.
Two groups of cells regulate the formation and resorption of bone matrix:
1) Bone cells called osteoblasts are responsible for the formation of bone matrix.
2) Osteoclasts are modified white blood cells that are responsible for bone tissue resorption.
A complex collection of signalling hormones, proteins, and cell receptors regulate these two cell types in response to the ever-changing demands on bone tissue and other physiological processes. When there are too many osteoclasts or they become overactive, they resorb more matrix than the osteoblasts can make. The main feature of the clinical disorder known as osteoporosis is a predominance of osteoclast involvement, which causes the bone to become less dense.
Cannabidiol binds to a particular cannabinoid receptor on bone-resorbing osteoblast cells, according to Aberdeen researchers. By doing so, it prevents these cells from resorbing the bone matrix, thus preventing further bone deterioration.
Plant compounds have previously been shown to affect bone metabolism in favour of stronger bones. Researchers at Oklahoma State University in the United States discovered in January 2009 that polyphenols derived from plums inhibit the action of bone-softening osteoclasts while increasing the generation and operation of bone-building osteoblasts, even in the presence of oxidative stress and systemic inflammation.
Many who believe that smoking marijuana can help strengthen their bones are mistaken. While wild cannabis contains up to 40% cannabidiol, cultivated cannabis varieties contain very little. The most significant takeaway from this study, in my view, is that it demonstrates the importance of plant compounds in the prevention of chronic degenerative diseases like osteoporosis. There are undoubtedly many more phytonutrients in other food plants that have a beneficial impact on bone metabolism that have yet to be “discovered.”